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DTSTAMP:20260614T223846Z
SUMMARY:Study\, detection and classification of cell cycle orbits along wit
 h circadian rhythm corresponding to different cell types in single cell da
 ta
DESCRIPTION:Contact: anders.rantzer@control.lth.se\n\nAll seminars are held
  at the Department of Automatic Control\, in the seminar room M 3170-73 on
  the third floor in the M-building\, unless stated otherwise.Master Thesis
  presentation by Archana Mallick and Nguyen Duc CuongTitle:&nbsp\; Study\,
  detection and classification of cell cycle orbits along with circadian rh
 ythm corresponding to different cell types in single cell dataAuthor:&nbsp
 \;Archana Mallick and Nguyen Duc CuongDate &amp\; Time:&nbsp\;June 4th\, 1
 0:30–11:00Location:&nbsp\;Seminar Room M 3170-73 in the M-building\, LTH
 Supervisor: Anders Rantzer and David OhlinExaminer:&nbsp\; Magnus FontesAb
 stractSingle-cell RNA sequencing (scRNA-seq) enables the study of how circ
 adian rhythms interact with cell cycle progression at the level of individ
 ual cells. In this thesis\, publicly available scRNA-seq data from healthy
  human bone marrow are used to analyze this relationship. Circadian phase 
 is inferred for each cell based on the expression of core clock genes\, an
 d rhythmic genes are identified using harmonic modeling. Cell cycle activi
 ty is quantified using established S-phase and G2/M gene signatures\, alon
 gside a data-driven approach to identify additional phase-specific marker 
 genes through differential expression analysis. This work also proposes a 
 computational framework to identify and extend cell-cycle marker genes\, p
 roviding deeper insight into temporal transcriptional regulation in the he
 matopoietic system and offering potential gene signatures for detecting ab
 normal proliferation and identifying tumor cells.\n\nMore information abou
 t the event: https://www.control.lth.se/calendar/study-detection-and-class
 ification-cell-cycle-orbits-along-circadian-rhythm-corresponding-different
DTSTART;TZID=GMT:20260604T083053
DTEND;TZID=GMT:20260604T090053
LOCATION:Seminar Room M 3170-73 in the M-building\, LTH
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